The vehicle rollover prevention system based on the detection of three-dimensional center of gravity can solve the problem of vehicle rollover when passing through curves. When a vehicle passes through a curve, it is subjected to a centrifugal force applied to its center of gravity, which may cause it to roll over. This system uses the detection of three-dimensional center of gravity theory to calculate the height of the center of gravity without knowing the vehicle's load capacity (m) and the elastic coefficient of the vehicle's spring (k), thereby calculating the maximum centrifugal force that the vehicle can withstand when passing through a curve without rollover, as well as the probability of the vehicle rollover, thereby preventing the vehicle from rollover. The effectiveness of this system has been proven through real vehicle operation experiments. Currently, the system, combined with autonomous driving technology, has achieved the fastest autonomous cornering without rollover through remote control car. The theory of detection of three-dimensional center of gravity can also be applied to the detection of driver fatigue.